Start one
Reconciliation → choose the account → Start new.
Enter the statement date, the beginning balance and the ending balance exactly as they appear on the statement your bank sent.
Match
Upload the statement file and lines are matched to your transactions automatically by amount and date. Tick off what cleared. The difference at the top is what is still unexplained.
Close it
When the difference is zero, Close reconciliation. The period is now proven and dated.
When it will not balance
The difference is almost always one of four things:
Cancelling
Cancel reconciliation throws away the work in progress. It does not undo anything already closed.